Hospis Malaysia was established in 1991 as a company limited by guarantee. Its first ‘office’ was a room on the fourth floor of Assunta Hospital. In February 1992, Hospis Malaysia began its home care service in Petaling Jaya and service was extended to cover Kuala Lumpur in September 1992. In that year, Hospis Malaysia had 44 patients registered under its care.

In 1996, Hospis Malaysia began the construction works of its own building on leased land at Taman Sri Bahtera, Cheras. A fulltime CEO/Medical Director was appointed in June 1997 in view of the increasing clinical activities. The following years saw Hospis Malaysia's steady growth in the field of palliative care. More volunteers began joining Hospis Malaysia, which enabled the clinical team to expand its service to visit more patients and to cover more areas. The experience that the clinical team was obtaining created a potential for Hospis Malaysia to confidently set out into palliative care training and education. The first pallative care lecture by Hospis Malaysia was in 1997 for a group of medical undergraduates from Universiti Malaya.

With the completion and launch of its building in 1998, the idea of starting professional palliative care workshops for doctors and nurses became feasible. Hence, in 1999, Hospis Malaysia ran its first "Palliative Care Foundation" workshop. Where operations and governance were concerned, noteworthy changes that took place were the commencement of its Day Care activities in 2000, and the reshuffling of Council which saw our previous Chairman, the late Dato’ Francis Huang, taking over from the late Dato’ Dr. Peter Mooney in 2001. In 2002, Hospis Malaysia expanded its training capacity by offering more palliative care programs in collaboration with the Asia Pacific Hospice Palliative Care Network (APHN), thus placing itself more firmly in the local and international palliative care circle as a recognised palliative care service and training provider .

Since the time it began, Hospis Malaysia has attended to thousands of patients in Klang Valley, and has recorded immense growth, both in its capacity as a professional palliative care provider, and in its staff strength. From its simple beginnings with one nurse and two volunteer doctors, Hospis Malaysia has since grown into the largest hospice in Malaysia in terms of the number of patients it accepts each year, and with its full-time palliative care team comprising  of twenty nurses, four doctors, a pharmacist, and an occupational therapist.